Impact of pharmacogenomics on clinical outcomes in major depressive disorder in the GUIDED trial: A large, patient- and rater-blinded, randomized, controlled study

Severe depression patients? The first line from the study found in the Journal of Psychiatric Research in 2019 reading "Current prescribing practices for major depressive disorder (MDD) produce limited treatment success." is a large patient- and rater-blinded, randomized, controlled study worth reviewing. Guided care improves response and remission rates and reduces economic burden among patients with very severe depression.

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Preemptive Clinical Pharmacogenetics Implementation: Current Programs in Five US Medical Centers

After decades have past in the field of Pharmacogenetics, overcoming barriers to adoption by providers utilizing pharmacogenetic testing (PGx) is gaining maturity. Readily available resources, including technology advances, reduction in costs, and insurer reimbursements are accelerating PGx testing as a new standard. In this article, they describe preemptive genotyping to optimize medications. In the back of a patients mind when facing a medication change, spoken or not, is "will this prescription change be my best med?" From common maintenance, multiple or high risk medications, standard genotyping results prior to prescribing decisions including genetics should be considered in the plan of a patient's care. This review describes common elements for RX Alerts utilizing genotyping and presents key process applications including clinical decision guidance.

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